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Sebastian Seung

Princeton Neuroscience Institute

June 25, 2025

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VVTNS Fifth Season Closing Lecture

​Insights into vision from interpreting a neuronal wiring diagram​

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In 2023, the FlyWire Consortium released the neuronal wiring diagram of an adult fly brain. This contains as a corollary the first complete wiring diagram of a visual system, which has been used to identify all 200+ cell types that are intrinsic to the Drosophila optic lobe. About half of these cell types were previously unknown, and less than 20% have ever been recorded by a physiologist. I will argue that plausible functions for many cell types can be guessed by interpreting the wiring diagram.

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