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Wednesday, 5 pm CET, i.e, 11 am ET


Organized by David Hansel, Ran Darshan & Carl van Vreeswijk* 


About Us

About the Seminar

VVTNS  is a weekly digital seminar on Zoom targeting the theoretical neuroscience community. Created as the World Wide Neuroscience Seminar (WWTNS) in November 2020 and renamed in homage to Carl van Vreeswijk in Memoriam (April 20, 2022), its aim is to be a platform to exchange ideas among theoreticians. Speakers have the occasion to talk about theoretical aspects of their work which cannot be discussed in a setting where the majority of the audience consists of experimentalists. The seminars  are 45 min long followed by a discussion and are held on Wednesdays at 11 am EST. The talks are recorded with authorization of the speaker and are available to everybody on our YouTube channel.


To participate in the seminar you need to fill out a registration form after which you will

receive an email telling you how to connect.

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Soledad Gonzalo Cogno


February 1, 2023

Minute-scale periodic sequences in medial entorhinal cortex

The medial entorhinal cortex (MEC) hosts many of the brain’s circuit elements for spatial navigation and episodic memory, operations that require neural activity to be organized across long durations of experience. While location is known to be encoded by a plethora of spatially tuned cell types in this brain region, little is known about how the activity of entorhinal cells is tied together over time. Among the brain’s most powerful mechanisms for neural coordination are network oscillations, which dynamically synchronize neural activity across circuit elements. In MEC, theta and gamma oscillations provide temporal structure to the neural population activity at subsecond time scales. It remains an open question, however, whether similarly coordination occurs in MEC at behavioural time scales, in the second-to-minute regime. In this talk I will show that MEC activity can be organized into a minute-scale oscillation that entrains nearly the entire cell population, with periods ranging from 10 to 100 seconds. Throughout this ultraslow oscillation, neural activity progresses in periodic and stereotyped sequences. The oscillation sometimes advances uninterruptedly for tens of minutes, transcending epochs of locomotion and immobility. Similar oscillatory sequences were not observed in neighboring parasubiculum or in visual cortex. The ultraslow periodic sequences in MEC may have the potential to couple its neurons and circuits across extended time scales and to serve as a scaffold for processes that unfold at behavioural time scales.



David Hansel

I am a theoretical neuroscientist at the National Center for Scientific Research in Paris, France and visiting professor at The Hebrew University in Jerusalem, Israel. I am mainly interested in the recurrent dynamics in the cortex and 

basal ganglia.

Carl van Vreeswijk *

I am a theoretical neuroscientist working at the National Center for Scientific Research in Paris, France. My main interest is the dynamics of recurrent networks of neurons in the sensory system


©2020 by WWTNS

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